Background: Recent studies have shown that cytokines have an important role in the pathogenesis of inflammatory diseases and can be used as prognostic markers. Objective: To evaluate the IL-6/IL-10 ratio in patients with Inherited Epidermolysis Bullosa (EB) as a prognostic marker. Methods: Serum levels of IL-6 and IL-10 were measured in 13 patients with recessive dystrophic EB (RDEB) as well as...

Background: As a chronic inflammatory condition, psoriasis results from an interaction between genetic and immunologic factors in a predisposing environment. In spite of compelling evidence for the role of T cells and cytokines in psoriasis, interleukin (IL)- 10 and IL-22 have not been sufficiently investigated. Objective: To assess the serum levels of IL-10 and IL-22 in patients with psori...

“T I drew, using a mirror; it is my own likeness, in the year 1484, when I was still a child,” wrote Albrecht Dürer about his first self-portrait, sketched with great confidence and skill when he was 13 years old (1). Fascinated by his own image, he continued to paint it throughout his life. His faithful dog once barked and wagged its tail at a newly completed self-portrait of his master, relat...

background & objective: interleukin (il)-10 is an important anti-inflammatory and immunomodulatory cytokine. some authors believe that single nucleotide polymorphisms (snp) in the promoter region of the il-10 gene have been associated with susceptibility to hiv infection and progression to aids, but its role is not clearly defined yet. the present study was undertaken to evaluate the associ...

Epstein–Barr virus is primarily the cause of acute infectious mononucleosis and can also cause lymphoma and autoimmune diseases. Th17 cells, which are a unique subset of ThCD4+ cells, direct the infection toward inflammation through production of inflammatory cytokine IL-17. In contrast, Treg Foxp3 cells inhibit inflammation through secretion of anti-inflammatory cytokine IL-10, leading to chro...

The serum level of ILL-4, -8, -10, -18 has been studied in 32 healthy women with uncomplicated pregnancy comparison nonpregnant women. It shown that the decreased production -10 and IL-8/IL-18 ratio, but increased IL-18 IL-18/IL-10 ratio.